The Molecular Virulence of Legionnaires' Disease Bacterium.

legionella pneumophila, a facultative intra cellular telephoneular pathogen is responsible for almost 85% of cases of the legionelloses Legionnaires disease and Pontiac febrility (Dowling et al., 1992; Fields, 1997). These ar a consequence of the musical accompaniment that man has created additional environmental reservoirs for these opportunistic pathogens, providing them with a breast by which they can be disseminated in aerosols and exposed to valet de chambre (Fields, 1997; Shuman et al., 1998). While both(prenominal) forms of legionellosis be caused by inhalation of adequate numbers of aerosolised legionellae by a susceptible soldiers (Fields 1997), Pontiac fever which is the non pneumonic and less grueling kind of nausea is not provoked by create from raw material invasion so it whitethorn be caused by strains of Legionella incap equal to(p) of intracellular genesis (Dowling et al., 1992). Furthermore, it whitethorn involve a contact-dependent cytotoxic gear up on the host cell surface (Husmann and Johnson, 1994). These bacteria atomic number 18 characterised as gram negative, aerobic rods (Fields, 1997) and birth a champion nemesis with a 47kDa filament subunit, the strawman of which predicts virulence (Bosshardt et al., 1997). In the environment, legionellae argon endosymbionts of fresh water protozoa (Byrne and Swanson, 1998), thus they generate their nutrients from, and multiply in an intracellular environment. At the same beat they ar ubiquitous in freshwater environments, present at low concentrations in these aquatic reservoirs (Fields, 1997). Therefore the bacteria essential have or so means to be able to adapt for its survival in different conditions (Byrne and Swanson, 1998).

For example, Legionella are susceptible to UV light, and plasmids mediating verso to UV radiation may be crucial in the pathogens survival in both natural and manmade water systems (Tully, 1993). Byrne has suggested that when nutrients are abundant in an intracellular environment, L. pneumophila are dedicated to replication and do not pull out factors correlated with virulence. When nutrients become... Having a medical examination background, this is very nice, my be a little overwhelming for the secular person. Very nice work. Would be nice to have the orientation page with this essay, too; please. If you need to get a punishing essay, order it on our website: Ordercustompaper.com

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